Eliza Pratt Greatorex (1819–1897) was America’s most famous woman artist in the mid-nineteenth century, but today she is all but forgotten. Beginning with her Irish roots, this biography brings her art and life back into focus. Unusually for a woman, she specialized in landscape and streetscapes, traveling from the Hudson River to the Colorado Rockies and across Europe and North Africa. Her magnum opus—graphics of Old New York— awakened the public to the destruction of the city’s architectural heritage during the post-Civil War era. Exploring Greatorex’s fierce ambition and creative path, Katherine Manthorne reveals how one woman forged an independent career in a male-dominated world to help shape American gender-politics, visual culture, and urban consciousness.